

This similarity makes it difficult to make a diagnosis based only on the signs and symptoms. The clinical manifestations caused by these viruses are not specific and often resemble each other. The four serotypes of DENV that are currently known (DENV 1–4) and ZIKV are flaviviruses belonging to the Flaviviridae family, while CHIKV is an alphavirus belonging to the Togaviridae family. Among the most important arboviruses in recent years are dengue virus (DENV), chikungunya virus (CHIKV), and zika virus (ZIKV).


The funders had no role in study design, data collection and analysis, decisión to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.Īrboviruses (for arthropod-borne viruses) are a heterogeneous group of viruses that, as a common characteristic, require the participation of arthropod vectors for their transmission between hosts. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the manuscript and its Supporting Information files.įunding: This study was supported by the Instituto Mexicano del Seguro Social (FIS/IMSS/PROT/G18/1810 to JEMM), the Consejo Nacional de Ciencia y Tecnología (478378 to LFM). Received: Accepted: OctoPublished: December 2, 2021Ĭopyright: © 2021 Fernandes-Matano et al. Messer, Oregon Health and Science University, UNITED STATES PLoS Negl Trop Dis 15(12):Įditor: William B. (2021) Impact of the introduction of chikungunya and zika viruses on the incidence of dengue in endemic zones of Mexico. Thus, the present study lays the foundations for a better preparation for the arrival of other arboviruses, showing the need for the development and implementation of multiplex diagnostic techniques, in addition to providing more precise epidemiological information on this historical moment of co-circulation of these three arboviruses in our country.Ĭitation: Fernandes-Matano L, Monroy-Muñoz IE, Pardavé-Alejandre HD, Uribe-Noguez LA, Hernández-Cueto MdlA, Rojas-Mendoza T, et al. We were also able to detect cases of coinfection, which had never been reported in Mexico. We discovered that there was indeed an underestimation of cases, mostly of chikungunya and Zika but, contrary to what we imagined, a lower degree of dengue. Therefore, we decided to reanalyze 1038 suspected cases of dengue, chikungunya and Zika samples using a test that could identify any of the three viruses in a single reaction. This led us to suspect that this decrease was not coincidental and could be attributed to two factors: the lack of expertise on the part of health teams to identify the clinical etiological agent and/or other complex ecological factors. With the arrival of the CHIKV and ZIKV, this number decreased considerably.

Mexico is considered an endemic country for DENV as the number of cases each year is high.
